health systems

Take control of chronic conditions.

True employee engagement, clinical outcomes, and cost control across the entire chronic care journey is the reality, with Manifold.

Flexible Programs and Pricing

Conquer the complexities of
chronic care

For health systems participating in value-based care and accountable care models, chronic conditions remain one of the largest drivers of utilization, readmissions, and total cost of care. To improve outcomes and financial performance, organizations must look beyond episodic clinical encounters and address avoidable issues such as low screening rates, poor follow-up, delayed risk identification, care gaps, and limited visibility into patient health between visits. These are the factors that ultimately drive utilization, quality metrics, and long-term costs.

Most traditional approaches are reactive, relying on claims data and interventions that arrive too late to meaningfully change outcomes. With Manifold, health systems gain continuous visibility into population health through self-collected blood testing, longitudinal monitoring, and proactive care management—helping improve quality performance, reduce avoidable utilization, and succeed under value-based care arrangements.

The Manifold Health shift, straight from our clients

Clara Nguyen

Head of Clinical Care

"Manifold changed how we manage patients between visits. The at-home collection means people actually follow through, no lab trips, no missed draws, so we finally have continuous biological data instead of reading symptoms and guessing. We can see exactly how each patient is responding over time and step in early."

52%

Increased Bloodwork Completion

3.2x

Therapy Adherence

Darius Finch

Finance Director

“Before Manifold Health, we were reacting to symptoms, fragmented data, and late-stage diagnoses. Now we have a unified view of biology, early risk signals, and predictive insight — which means fewer surprises and more time to focus on prevention and long-term health outcomes.”

3.4 h

Saved per team member each week

45%

Fewer manual reconciliation tasks

Meera Shah

Controller

“Manifold Health helped us move from reactive care to earlier insight. Our biological data is cleaner, our models are more reliable, and we finally trust the signals we’re seeing.”

48%

Faster month-end close

32%

Increase in internal team satisfaction

Clara Nguyen

Head of Clinical Care

"Manifold changed how we manage patients between visits. The at-home collection means people actually follow through, no lab trips, no missed draws, so we finally have continuous biological data instead of reading symptoms and guessing. We can see exactly how each patient is responding over time and step in early."

52%

Increased Bloodwork Completion

3.2x

Therapy Adherence

Darius Finch

Finance Director

“Before Manifold Health, we were reacting to symptoms, fragmented data, and late-stage diagnoses. Now we have a unified view of biology, early risk signals, and predictive insight — which means fewer surprises and more time to focus on prevention and long-term health outcomes.”

3.4 h

Saved per team member each week

45%

Fewer manual reconciliation tasks

Meera Shah

Controller

“Manifold Health helped us move from reactive care to earlier insight. Our biological data is cleaner, our models are more reliable, and we finally trust the signals we’re seeing.”

48%

Faster month-end close

32%

Increase in internal team satisfaction

Clara Nguyen

Head of Clinical Care

"Manifold changed how we manage patients between visits. The at-home collection means people actually follow through, no lab trips, no missed draws, so we finally have continuous biological data instead of reading symptoms and guessing. We can see exactly how each patient is responding over time and step in early."

52%

Increased Bloodwork Completion

3.2x

Therapy Adherence

Darius Finch

Finance Director

“Before Manifold Health, we were reacting to symptoms, fragmented data, and late-stage diagnoses. Now we have a unified view of biology, early risk signals, and predictive insight — which means fewer surprises and more time to focus on prevention and long-term health outcomes.”

3.4 h

Saved per team member each week

45%

Fewer manual reconciliation tasks

Meera Shah

Controller

“Manifold Health helped us move from reactive care to earlier insight. Our biological data is cleaner, our models are more reliable, and we finally trust the signals we’re seeing.”

48%

Faster month-end close

32%

Increase in internal team satisfaction

What Manifold delivers

What Manifold delivers

74% of lifestyle-related deaths are caused by chronic conditions.

0%

74% of lifestyle-related deaths are caused by chronic conditions.

0%

74% of lifestyle-related deaths are caused by chronic conditions.

0%

>53% reduction in prescription use among ages 45-79.

0+

>53% reduction in prescription use among ages 45-79.

0+

>53% reduction in prescription use among ages 45-79.

0+

Chronic conditions can cost up to seven times more than if they had been prevented.

0x

Chronic conditions can cost up to seven times more than if they had been prevented.

0x

Chronic conditions can cost up to seven times more than if they had been prevented.

0x

saved per patient

$0

saved per patient

$0

saved per patient

$0

GLP-1 Removal

$0

GLP-1 Removal

$0

GLP-1 Removal

$0

Return on Investment in Year 1

0x

Return on Investment in Year 1

0x

Return on Investment in Year 1

0x

PREVENTATIVE HEALTH

Detect conditions earlier, prevent expensive health costs.

Every lifestyle-related chronic condition managed earlier saves tens of thousands in treatment costs and delivers 2–3x better health outcomes on average.

Continuous biological monitoring

Track key biological systems over time as new blood data is collected. Manifold Health updates the Digital Health Twin continuously—revealing subtle changes long before clinical symptoms emerge.

Continuous biological monitoring

Track key biological systems over time as new blood data is collected. Manifold Health updates the Digital Health Twin continuously—revealing subtle changes long before clinical symptoms emerge.

Continuous biological monitoring

Track key biological systems over time as new blood data is collected. Manifold Health updates the Digital Health Twin continuously—revealing subtle changes long before clinical symptoms emerge.

System-level thresholds limits & rules

Define biologically meaningful ranges across metabolic, inflammatory, cardiovascular, and hormonal systems. Our models evaluate how signals interact—rather than relying on isolated biomarkers.

System-level thresholds limits & rules

Define biologically meaningful ranges across metabolic, inflammatory, cardiovascular, and hormonal systems. Our models evaluate how signals interact—rather than relying on isolated biomarkers.

System-level thresholds limits & rules

Define biologically meaningful ranges across metabolic, inflammatory, cardiovascular, and hormonal systems. Our models evaluate how signals interact—rather than relying on isolated biomarkers.

Early deviation detection

Identify when biology begins to drift from healthy trajectories. Manifold Health flags compounding risk patterns early—when intervention is still effective and outcomes are more favorable.

Early deviation detection

Identify when biology begins to drift from healthy trajectories. Manifold Health flags compounding risk patterns early—when intervention is still effective and outcomes are more favorable.

Early deviation detection

Identify when biology begins to drift from healthy trajectories. Manifold Health flags compounding risk patterns early—when intervention is still effective and outcomes are more favorable.

Woman holding a smartphone looking through the glass

Key Insights

Focused on the key conditions responsible for most preventable diseases.

Woman holding a smartphone looking through the glass

Key Insights

Focused on the key conditions responsible for most preventable diseases.

Woman holding a smartphone looking through the glass

Key Insights

Focused on the key conditions responsible for most preventable diseases.

Frequently asked questions

How does Manifold support health systems participating in value-based care?
icon

Manifold helps health systems identify risk earlier, engage patients more effectively, and monitor health continuously between clinical encounters. Through self-collected blood testing and longitudinal health intelligence, organizations gain greater visibility into patient populations, helping improve quality performance and reduce avoidable utilization.

How does Manifold help ACOs reduce total cost of care?
icon

Manifold addresses many of the drivers of avoidable healthcare spending, including delayed risk identification, poor follow-up, low patient engagement, unmanaged chronic conditions, and care gaps. By enabling earlier intervention and continuous monitoring, organizations can reduce downstream utilization and improve population health outcomes.

How does Manifold support population health initiatives?
icon

Manifold extends population health programs beyond the clinic by bringing screening, monitoring, and patient engagement directly into the home. This helps organizations reach more patients, improve participation rates, and maintain visibility into health status over time.

How does Manifold help close care gaps?
icon

Manifold uses biomarker monitoring, proactive outreach, and longitudinal health tracking to identify patients who may be missing screenings, follow-up care, or chronic disease management opportunities. This helps care teams prioritize interventions and improve quality performance.

Does Manifold replace existing care management programs?
icon

No. Manifold is designed to complement existing care management, disease management, and population health initiatives. We provide a continuous biological monitoring layer that helps organizations understand patient risk, engagement, and outcomes between traditional care encounters.

How does Manifold improve patient engagement?
icon

Manifold combines guided self-collected blood testing, digital engagement, and proactive monitoring to meet patients where they are. By reducing barriers to participation and making health information more accessible, organizations can improve adherence and long-term engagement.

How does Manifold support quality and risk-based contracts?
icon

y improving screening completion, patient engagement, chronic disease monitoring, and care gap closure, Manifold helps organizations improve performance across quality measures and value-based reimbursement programs while creating greater visibility into population health risk.

How does Manifold support health systems participating in value-based care?
icon

Manifold helps health systems identify risk earlier, engage patients more effectively, and monitor health continuously between clinical encounters. Through self-collected blood testing and longitudinal health intelligence, organizations gain greater visibility into patient populations, helping improve quality performance and reduce avoidable utilization.

How does Manifold help ACOs reduce total cost of care?
icon

Manifold addresses many of the drivers of avoidable healthcare spending, including delayed risk identification, poor follow-up, low patient engagement, unmanaged chronic conditions, and care gaps. By enabling earlier intervention and continuous monitoring, organizations can reduce downstream utilization and improve population health outcomes.

How does Manifold support population health initiatives?
icon

Manifold extends population health programs beyond the clinic by bringing screening, monitoring, and patient engagement directly into the home. This helps organizations reach more patients, improve participation rates, and maintain visibility into health status over time.

How does Manifold help close care gaps?
icon

Manifold uses biomarker monitoring, proactive outreach, and longitudinal health tracking to identify patients who may be missing screenings, follow-up care, or chronic disease management opportunities. This helps care teams prioritize interventions and improve quality performance.

Does Manifold replace existing care management programs?
icon

No. Manifold is designed to complement existing care management, disease management, and population health initiatives. We provide a continuous biological monitoring layer that helps organizations understand patient risk, engagement, and outcomes between traditional care encounters.

How does Manifold improve patient engagement?
icon

Manifold combines guided self-collected blood testing, digital engagement, and proactive monitoring to meet patients where they are. By reducing barriers to participation and making health information more accessible, organizations can improve adherence and long-term engagement.

How does Manifold support quality and risk-based contracts?
icon

y improving screening completion, patient engagement, chronic disease monitoring, and care gap closure, Manifold helps organizations improve performance across quality measures and value-based reimbursement programs while creating greater visibility into population health risk.

How does Manifold support health systems participating in value-based care?
icon

Manifold helps health systems identify risk earlier, engage patients more effectively, and monitor health continuously between clinical encounters. Through self-collected blood testing and longitudinal health intelligence, organizations gain greater visibility into patient populations, helping improve quality performance and reduce avoidable utilization.

How does Manifold help ACOs reduce total cost of care?
icon

Manifold addresses many of the drivers of avoidable healthcare spending, including delayed risk identification, poor follow-up, low patient engagement, unmanaged chronic conditions, and care gaps. By enabling earlier intervention and continuous monitoring, organizations can reduce downstream utilization and improve population health outcomes.

How does Manifold support population health initiatives?
icon

Manifold extends population health programs beyond the clinic by bringing screening, monitoring, and patient engagement directly into the home. This helps organizations reach more patients, improve participation rates, and maintain visibility into health status over time.

How does Manifold help close care gaps?
icon

Manifold uses biomarker monitoring, proactive outreach, and longitudinal health tracking to identify patients who may be missing screenings, follow-up care, or chronic disease management opportunities. This helps care teams prioritize interventions and improve quality performance.

Does Manifold replace existing care management programs?
icon

No. Manifold is designed to complement existing care management, disease management, and population health initiatives. We provide a continuous biological monitoring layer that helps organizations understand patient risk, engagement, and outcomes between traditional care encounters.

How does Manifold improve patient engagement?
icon

Manifold combines guided self-collected blood testing, digital engagement, and proactive monitoring to meet patients where they are. By reducing barriers to participation and making health information more accessible, organizations can improve adherence and long-term engagement.

How does Manifold support quality and risk-based contracts?
icon

y improving screening completion, patient engagement, chronic disease monitoring, and care gap closure, Manifold helps organizations improve performance across quality measures and value-based reimbursement programs while creating greater visibility into population health risk.

New York, NY, USA

@ 2025 Manifold Health All rights reserved

Manifold Health is a health intelligence software provider, not a healthcare provider, insurer, health plan, or medical device manufacturer. The services provided by Manifold Health are intended solely for business and enterprise use and do not include the provision of medical care, diagnosis, treatment, insurance coverage, or payment processing. Manifold Health’s platform is designed to enhance visibility, automation, and decision-making across population health, risk modeling, and cost management workflows. Insights generated by the platform are intended for informational and operational planning purposes only and should not be interpreted as medical advice, clinical guidance, underwriting determinations, or a substitute for professional medical, actuarial, legal, or financial consultation. Access to the Manifold Health platform is subject to our Terms of Use and Privacy Policy. Data entered into the platform is processed in accordance with applicable data protection and privacy laws and stored using enterprise-grade security controls. Manifold Health makes no representations or guarantees regarding clinical outcomes, cost savings, compliance determinations, underwriting decisions, or financial performance resulting from use of the platform. All third-party data sources, integrations, and APIs are provided “as is,” and Manifold Health assumes no responsibility for the accuracy, availability, or continued support of connected services. Manifold Health does not perform claims adjudication, insurance underwriting, regulatory reporting, or clinical decision-making unless explicitly agreed upon through a written service agreement. Use of the Manifold Health platform may involve the transmission of health, claims, eligibility, or laboratory data through secure APIs or manually uploaded files. Customers are solely responsible for ensuring the accuracy of their data, maintaining compliance with applicable laws and regulations (including HIPAA where applicable), and determining how platform insights are used within their organization. Any predictive models, forecasts, or AI-driven insights provided by Manifold Health are forward-looking in nature and should not be relied upon as the sole basis for healthcare, coverage, or financial decisions. Manifold Health is not intended for personal or consumer use. Availability of features—including analytics, forecasting, and automation—may vary by plan level, data source, and geographic region. Manifold Health, Inc. is a privately held company registered in the United States of America. For questions regarding platform usage, licensing, data security, or compliance, please refer to our Help Center or contact support@manifoldhealth.ai.

New York, NY, USA

@ 2025 Manifold Health All rights reserved

Manifold Health is a health intelligence software provider, not a healthcare provider, insurer, health plan, or medical device manufacturer. The services provided by Manifold Health are intended solely for business and enterprise use and do not include the provision of medical care, diagnosis, treatment, insurance coverage, or payment processing. Manifold Health’s platform is designed to enhance visibility, automation, and decision-making across population health, risk modeling, and cost management workflows. Insights generated by the platform are intended for informational and operational planning purposes only and should not be interpreted as medical advice, clinical guidance, underwriting determinations, or a substitute for professional medical, actuarial, legal, or financial consultation. Access to the Manifold Health platform is subject to our Terms of Use and Privacy Policy. Data entered into the platform is processed in accordance with applicable data protection and privacy laws and stored using enterprise-grade security controls. Manifold Health makes no representations or guarantees regarding clinical outcomes, cost savings, compliance determinations, underwriting decisions, or financial performance resulting from use of the platform. All third-party data sources, integrations, and APIs are provided “as is,” and Manifold Health assumes no responsibility for the accuracy, availability, or continued support of connected services. Manifold Health does not perform claims adjudication, insurance underwriting, regulatory reporting, or clinical decision-making unless explicitly agreed upon through a written service agreement. Use of the Manifold Health platform may involve the transmission of health, claims, eligibility, or laboratory data through secure APIs or manually uploaded files. Customers are solely responsible for ensuring the accuracy of their data, maintaining compliance with applicable laws and regulations (including HIPAA where applicable), and determining how platform insights are used within their organization. Any predictive models, forecasts, or AI-driven insights provided by Manifold Health are forward-looking in nature and should not be relied upon as the sole basis for healthcare, coverage, or financial decisions. Manifold Health is not intended for personal or consumer use. Availability of features—including analytics, forecasting, and automation—may vary by plan level, data source, and geographic region. Manifold Health, Inc. is a privately held company registered in the United States of America. For questions regarding platform usage, licensing, data security, or compliance, please refer to our Help Center or contact support@manifoldhealth.ai.

New York, NY, USA

@ 2025 Manifold Health All rights reserved

Manifold Health is a health intelligence software provider, not a healthcare provider, insurer, health plan, or medical device manufacturer. The services provided by Manifold Health are intended solely for business and enterprise use and do not include the provision of medical care, diagnosis, treatment, insurance coverage, or payment processing. Manifold Health’s platform is designed to enhance visibility, automation, and decision-making across population health, risk modeling, and cost management workflows. Insights generated by the platform are intended for informational and operational planning purposes only and should not be interpreted as medical advice, clinical guidance, underwriting determinations, or a substitute for professional medical, actuarial, legal, or financial consultation. Access to the Manifold Health platform is subject to our Terms of Use and Privacy Policy. Data entered into the platform is processed in accordance with applicable data protection and privacy laws and stored using enterprise-grade security controls. Manifold Health makes no representations or guarantees regarding clinical outcomes, cost savings, compliance determinations, underwriting decisions, or financial performance resulting from use of the platform. All third-party data sources, integrations, and APIs are provided “as is,” and Manifold Health assumes no responsibility for the accuracy, availability, or continued support of connected services. Manifold Health does not perform claims adjudication, insurance underwriting, regulatory reporting, or clinical decision-making unless explicitly agreed upon through a written service agreement. Use of the Manifold Health platform may involve the transmission of health, claims, eligibility, or laboratory data through secure APIs or manually uploaded files. Customers are solely responsible for ensuring the accuracy of their data, maintaining compliance with applicable laws and regulations (including HIPAA where applicable), and determining how platform insights are used within their organization. Any predictive models, forecasts, or AI-driven insights provided by Manifold Health are forward-looking in nature and should not be relied upon as the sole basis for healthcare, coverage, or financial decisions. Manifold Health is not intended for personal or consumer use. Availability of features—including analytics, forecasting, and automation—may vary by plan level, data source, and geographic region. Manifold Health, Inc. is a privately held company registered in the United States of America. For questions regarding platform usage, licensing, data security, or compliance, please refer to our Help Center or contact support@manifoldhealth.ai.